GAERS are a fully inbred strain of rats, derived from an outbred Wistar colony, with 100% of animals displaying the electroencephalography (EEG) and behavioral characteristic of absence seizures. The genetic absence epilepsy rats from Strasbourg (GAERS) are a well-validated model of human generalized absence epilepsy ( Marescaux et al., 1992 Danober et al., 1998). This widespread activation in GAERS involves the somatosensory cortex and thalamus, which are both known to be involved in the expression of absence seizures as well as numerous limbic regions thought not to play a role in the expression of absence seizures, suggesting an interaction between corticothalamocortical and limbic circuitries. The LCBF increase in the somatosensory cortex, ventrobasal and anterior thalamic nuclei, hypothalamus, subthalamic nucleus, piriform, entorhinal and perirhinal cortex, amygdala, CA2 region of hippocampus, and substantia nigra was statistically significantly larger in stimulated GAERS compared to stimulated NEC rats.Ĭonclusion: The results show that more brain regions are activated by kindling stimulation in GAERS. The LCBF increase in stimulated GAERS was larger and more widespread than that observed in stimulated NEC. Results: Rates of LCBF increased in stimulated GAERS and NEC groups compared to nonstimulated controls. The tracer infusion lasted for 60 s and started at 15 s before seizure induction. LCBF rates were measured bilaterally in 43 brain regions. Quantitative autoradiographic measurements of LCBF were performed by the -iodoantipyrine (IAP) autoradiographic technique allowing the precise mapping of regional perfusion changes. Methods: Electrodes were implanted in the amygdala of adult NEC and GAERS male rats, which were stimulated to reach stage 2. We studied local cerebral blood flow (LCBF) changes in brain regions involved in seizures in both GAERS and nonepileptic rats (NEC) to map the differences that may be related to the resistance to kindling. Purpose: Genetic absence epilepsy rats from Strasbourg (GAERS) are resistant to the progression of kindling seizures.
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